A1 Adenosine Receptor Properties in Drug-induced Torpor

The purpose of the proposed research is to investigate mechanisms that regulate the onset of torpor in hibernating mammals. The long term goal of this research is to induce aspects of torpor in nonhibernating species as a means to avoid adverse consequences of prolonged space flight. The ability to induce these or other related aspects of tropor in nonhibernating species may lead to strategies to reduce negative impacts of long-term space flight on human health such as loss of bone density.